Selected Publications of the Drosatos Lab
June 2025
June 2025
Empagliflozin restores cardiac metabolism and suppresses immune activation in acute myocardial infarction.
Mylonas N, Nikolaou PE, Siokatas G, Kostopoulos IV, Tsitsilonis O, Drosatos K, Andreadou I.
May 2025
June 2025
Hepato-cardiac interorgan communication controls cardiac hypertrophy via combined endocrine-autocrine FGF21 signaling
Sobuj Mia, Georgios Siokatas, Rafailia Sidiropoulou, Matthew Hoffman, Konstantinos Fragkiadakis, Eftychia Markopoulou, Mahmoud I. Elesawy, Rajika Roy, Scott Blair, Yasuhide Kuwabara, Erjola Rapushi, Dipayan Chaudhuri, Cath
Hepato-cardiac interorgan communication controls cardiac hypertrophy via combined endocrine-autocrine FGF21 signaling
Sobuj Mia, Georgios Siokatas, Rafailia Sidiropoulou, Matthew Hoffman, Konstantinos Fragkiadakis, Eftychia Markopoulou, Mahmoud I. Elesawy, Rajika Roy, Scott Blair, Yasuhide Kuwabara, Erjola Rapushi, Dipayan Chaudhuri, Catherine A. Makarewich, Erhe Gao, Walter J. Koch, Joel D. Schilling, Jeffery D. Molkentin, Maria Marketou, Konstantinos Drosatos
March 2025
Cardiac ischemia/reperfusion increases cardiomyocyte KLF5 in pigs and mice that aggravates tissue injury and remodeling
Nikolaos Mylonas, Georgios Siokatas , Effimia Zacharia , Christine Pol , Tyler Rolland , Ioannis D Kyriazis, Matthew Hoffman, Alycia Hildebrand, Thomas Bannister, Erhe Gao, Ira J Goldberg, Vincent W Yang, Agnieszka B Bia
Cardiac ischemia/reperfusion increases cardiomyocyte KLF5 in pigs and mice that aggravates tissue injury and remodeling
Nikolaos Mylonas, Georgios Siokatas , Effimia Zacharia , Christine Pol , Tyler Rolland , Ioannis D Kyriazis, Matthew Hoffman, Alycia Hildebrand, Thomas Bannister, Erhe Gao, Ira J Goldberg, Vincent W Yang, Agnieszka B Bialkowska, John Elrod, John M Canty Jr, Ioanna Andreadou, Brian Weil, Konstantinos Drosatos
February 2025
Roadmap for alleviating the manifestations of ageing in the cardiovascular system
Luca Liberale, Simon Tual-Chalot, Simon Sedej, Stefano Ministrini, Georgios Georgiopoulos, Myriam Grunewald, Magnus Bäck, Marie-Luce Bochaton-Piallat, Reinier A. Boon, Gustavo Campos Ramos, Menno P. J. de Winther, Konstantinos Drosatos, Paul C. Evans, Jane
Roadmap for alleviating the manifestations of ageing in the cardiovascular system
Luca Liberale, Simon Tual-Chalot, Simon Sedej, Stefano Ministrini, Georgios Georgiopoulos, Myriam Grunewald, Magnus Bäck, Marie-Luce Bochaton-Piallat, Reinier A. Boon, Gustavo Campos Ramos, Menno P. J. de Winther, Konstantinos Drosatos, Paul C. Evans, Jane F. Ferguson, Sofia K. Forslund-Startceva, Claudia Goettsch, Mauro Giacca, Judith Haendeler, Marinos Kallikourdis, Daniel F. J. Ketelhuth, Rory R. Koenen, Patrick Lacolley, Esther Lutgens, Pasquale Maffia, …Konstantinos Stellos
August 2024
February 2021
August 2024
Myocardial Krüppel-Like Factor 5 Abundance Holds Prognostic Value for Myocardial Recovery of Patients With Heart Failure Following Mechanical Unloading and Circulatory Support
Georgios Siokatas, Rana Hamouche, Eleni Maneta, Craig Selzman, Konstantinos E Hatzistergos, Stavros G Drakos, Konstantinos Drosatos.
March 2021
February 2021
August 2024
Cardiomyocyte Krüppel-Like Factor 5 Promotes De Novo Ceramide Biosynthesis and Contributes to Eccentric Remodeling in Ischemic Cardiomyopathy
Matthew Hoffman, Dimitra Palioura, Ioannis D Kyriazis, Maria Cimini, Rachit Badolia, Sudarsan Rajan, Erhe Gao, Nikolas Nikolaidis, P Christian Schulze, Ira J Goldberg, Raj Kishore, Vincent W Yang,
Cardiomyocyte Krüppel-Like Factor 5 Promotes De Novo Ceramide Biosynthesis and Contributes to Eccentric Remodeling in Ischemic Cardiomyopathy
Matthew Hoffman, Dimitra Palioura, Ioannis D Kyriazis, Maria Cimini, Rachit Badolia, Sudarsan Rajan, Erhe Gao, Nikolas Nikolaidis, P Christian Schulze, Ira J Goldberg, Raj Kishore, Vincent W Yang, Thomas D Bannister, Agnieszka B Bialkowska, Craig H Selzman, Stavros G Drakos, Konstantinos Drosatos
February 2021
February 2021
February 2021
KLF5 Is Induced by FOXO1 and Causes Oxidative Stress and Diabetic Cardiomyopathy
Ioannis D Kyriazis, Matthew Hoffman, Lea Gaignebet, Anna Maria Lucchese, Eftychia Markopoulou, Dimitra Palioura, Chao Wang, Thomas D Bannister, Melpo Christofidou-Solomidou, Shin-Ichi Oka, Junichi Sadoshima, Walter J Koch, Ira J Goldberg, Vincent W Yang, Agn
KLF5 Is Induced by FOXO1 and Causes Oxidative Stress and Diabetic Cardiomyopathy
Ioannis D Kyriazis, Matthew Hoffman, Lea Gaignebet, Anna Maria Lucchese, Eftychia Markopoulou, Dimitra Palioura, Chao Wang, Thomas D Bannister, Melpo Christofidou-Solomidou, Shin-Ichi Oka, Junichi Sadoshima, Walter J Koch, Ira J Goldberg, Vincent W Yang, Agnieszka B Bialkowska, Georgios Kararigas, Konstantinos Drosatos.
SELECTED FOR THE EDITORIAL
April 2020
February 2021
February 2021
B-type natriuretic peptide is upregulated by c-Jun N-terminal kinase and contributes to septic hypotension.
Hoffman M, Kyriazis ID, Dimitriou A, Mishra SK, Koch WJ, Drosatos K.
September 2019
September 2019
September 2019
Cardiac myocyte KLF5 regulates body weight via alteration of cardiac FGF21.
Pol CJ, Pollak NM, Jurczak MJ, Zacharia E, Karagiannides I, Kyriazis ID, Ntziachristos P, Scerbo DA, Brown BR, Aifantis I, Shulman GI, Goldberg IJ, Drosatos K
August 2019
September 2019
September 2019
Dual peroxisome-proliferator-activated-receptor-α/γ activation inhibits SIRT1-PGC1α axis and causes cardiac dysfunction.
Kalliora C, Kyriazis ID, Oka SI, Lieu MJ, Yue Y, Area-Gomez E, Pol CJ, Tian Y, Mizushima W, Chin A, Scerbo D, Schulze PC, Civelek M, Sadoshima J, Madesh M, Goldberg IJ, Drosatos K
May 2019
September 2019
February 2018
Myocardial Strain and Cardiac Output are Preferable Measurements for Cardiac Dysfunction and Can Predict Mortality in Septic Mice.
Hoffman M, Kyriazis ID, Lucchese AM, de Lucia C, Piedepalumbo M, Bauer M, Schulze PC, Bonios MJ, Koch WJ, Drosatos K
February 2018
September 2019
February 2018
Krüppel-like factors: Crippling and un-crippling metabolic pathways.
Pollak NM, Hoffman M, Goldberg IJ, Drosatos K